Dr. Maria Linder, Chemistry

Education and Professional Positions

B.A. in Chemistry, Vassar College, Poughkeepsie NY, 1960
PhD, Biochemistry, Harvard University, Cambridge, MA, 1966
Post doc, Biological Chemistry, Harvard Medical School, Boston, MA, 1966-1968
Post doc, Physiological Chemistry, MIT, Cambridge, MA, 1968-1970
1970-1971, Research Associate, Physiological Chemistry, MIT, Dept. of Nutrition and Food Science. 
1971-1977, Assistant and Associate Professor of Physiological Chemistry, MIT, Department of Nutrition and Food Science. 
1976-1977, Visiting Professor, Dept. of Chemistry, Cal Tech.   
1977 - Present, Associate and Full Professor of Biochemistry, Dept. of Chemistry and Biochemistry, California State University, Fullerton, CA.  
1992-1993, Visiting Professor, Dept. of Cell Biology, NYU School of Medicine 
2004-Present, Chair, Department of Chemistry and Biochemistry

Current Research Interests

Structure, function and regulation of mammalian proteins associated with copper and iron transport and storage, with particular reference to copper transport from mother to fetus in pregnancy and lactation; the mechanisms of release of iron stored in cells and its shuttling into and out of cellular proteins and compartments; nutritional biochemistry of trace elements.

Selected Publications

  1. Linder, M.C. (2010) Nutritional biochemistry of copper, with emphasis on the perinatal period.  In: Biochemical Aspects of Human Nutrition (L. Avigliano and L. Rossi, eds.), ISBN 978-81-7895-478-3. Transworld Research Network, Trivandrum, Kerala, India, pp. 143-179, in press.
  2. Moriya, M., Ho, Y-H., Grana, A., Nguyen, L., Alvarez, A., Jamil,, R., Ackland, M.L., Michalczyk, A., Hamer, P., Ramos,, D. Kim, S., Mercer, J.F.B., and Linder, M.C. (2008) Copper is taken up efficiently from albumin and alpha-2-macroglobulin by cultured human cells by more than one mechanism.  Am. J. Physiol. (Cell Physiology) 295: 708-721.
  3. Liu, N.M., Lo, L.S.L., Askary, S.H., Jones, L.T., Nguyen, T.T.M., Kidane, T.Z., Goforth, J., Vivas, E., Tsai, M.T., Westbrook, T. and Linder, M.C.  (2007) Transcuprein is a macroglobulin regulated by copper availability. J. Nutritional Biochem. 18: 597-608.
  4. Kidane,, T.Z., Sauble, E. and Linder, M.C. (2006) In three cell types, release of iron from ferritin requires lysosomal activity.  Am. J. Physiol. (Cell Biol.) 291: C445-C455.
  5. Donley, S.A., Ilagan, B.J., Rim, H. and Linder, M.C. (2002)  Copper transport to mammary gland and milk during lactation in rats.  Am. J. Physiol. (Endoc. Metab.), 283, E667-E675.

Honors and Awards